Natustat™ has been uniquely formulated to assist in preventing the build up of high levels of cholesterol. Only the most sophisticated technology is employed to deliver a product of exceptional uality. Natustat™ is free of all allergies associated with wheat, diary, alcohol, gluten, preservatives and colourants.

This product is not intended to diagnose, treat, cure or prevent any disease. Do not use without supervision if you suffer from any serious ailments or if you are pregnant or breastfeeding.


Cholesterol, a lipid (fatty) component of all cellular membranes, is required to support cellular integrity and for the biosynthesis of vital hormones and for the production of bile acids which are responsible for the breakdown of foodstuffs. Cholesterol levels can be influenced by dietary modification (i.e. reducing one's intake of saturated and transfatty acids) but the majority of cholesterol (50 - 80%) isn't derived from dietary sources but is synthesised by the liver. Biosynthesis of cholesterol is controlled by the rate-limiting enzyme, HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase. Normally, cholesterol levels are regulated by the liver via a biochemical feedback loop.

When cholesterol levels are low, live production of HMG-CoA reductase leads to increased biosynthesis of cholesterol. Conversely, when cholesterol levels are elevated, the liver reduces production of HMG-CoA reductase, halting further production of cholesterol. The proper functioning of this feedback mechanism is vital for the maintenance of healthy cholesterol levels. Unfortunately, modern dietary habits and lifestyle contribute to the disruption of this system, leading to elevated cholesterol levels and increased risks of developing CHD.

A newly available food-source supplement has recently been shown effective in lowering total cholesterol levels, reducing LDL ('bad cholesterol') and tryglyceride levels, and increasing HDL ('good cholesterol') levels. The supplement, Red Yeast Rice extract, is an exciting new addition to the existing armamentarium of natural supplements that have been shown to safely and effectively reduce moderately elevated cholesterol levels.

In the first American study on red yeast rice, researchers recorded benefits consistent with the scientific studies in China. Dr David Heber of the University of California in Los Angeles published the report in the American Journal of Clinical Nutrition. The study, a 12-week, double blind, placebo-controlled study conducted in UCLA involved 83 volunteers taking a proprietary red yeast rice supplement. Total cholesterol concentrations decreased significantly in the red yeast rice-treated group compared with the placebo treated group. LDL cholesterol and total triglyceride were also reduced with the supplement. "LDL levels dropped 15% among patients taking the red yeast supplement over an 8 week period," said Dr Heber. "A 15% reduction is highly significant. Individuals following a very strict diet - without taking a cholesterol lowering supplement - can only expect to lower their cholesterol by 10% at most."

This ingredient, along with Allicin (Garlic Extract), CoQ10 (Coenzyme Q10) Folic Acid and Vitamins B3, B6 and B12 form a unique new product called Natustat™.

Homocysteine
What is homocysteine, and how is it related to cardiovascular risk?
Homocysteine is an amino acid in the blood. Epidemiological studies have shown that too much homocysteine in the blood is related to a higher risk of coronary heart disease, stroke and peripheral vascular disease. Homocysteine, a homologue of the amino acid cysteine, is produced by demethylation of methionine. It is an intermediate in the biosynthesis of cysteine from methionine via cystathionine. Moderate hyperhomocysteinemia has been linked to symptomatic peripheral vascular, cerebrovascular, and coronary artery disease.

Elevated plasma homocysteine levels have been shown to correlate with genetic background, as an independant initiated factor vis a vie raised serum cholesterol, diet, and directly with increasing age.
Elevated Plasma Homocysteine in the blood plasma is a significant risk factor for vascular disease including heart disease and stroke.

In 66% (80/122) of the cases with severe atherosclerosis, the disease developed without evidence of serum cholesterol, diabetes, or hypertension. Blood homocysteine, which has been shown by other studies to be an independent risk factor for atherosclerosis, is recommended for assessing prognosis in these cases.

Elevated plasma levels of homocysteine have been reported to be more prevalent in patients with coronary artery disease (CAD) than in controls. Homocysteine levels were determined in 176 men with premature CAD (> 50% stenosis of a major epicardial coronary artery occurring before the age of 60 years) and in 255 controls free of cardiovascular disease. Homocysteine levels were higher in the CAD group compared with the controls.

The final results of these tests indicated that homocysteine levels are in part genetically determined. 14% of CAD patients had familial hyperhomocysteinemia. Raised plasma homocysteine is a risk factor for the development of CAD, independent of other cardiovascular risk factors, and that this elevation is in part genetically determined. The vascular events in the homocystinuria include venous thrombosis with the pulmonary embolism, stroke and myocardial infarction.

Although vascular complications are often the cause of death in patients with homocystinuria, survival into adulthood is often seen, especially in those patients who respond to vitamin B6 Therapy. Deficiencies of vitamin B12, vitamin B6, or folate may underlie some cases of elevated homocysteine levels.

Homocysteine levels have been shown to be independent of lipid and lipoprotein cholesterol levels. CAD was defined as a 50% or greater cross-sectional stenosis of at least one of the main epicardial coronary arteries on multiple projections.

Red Yeast Rice Extract
To deal with the prohibitive cost of statins, researchers in China have been examining traditional Chinese medicinal compounds in a search for more affordable alternatives to controlling cholesterol levels. One of the most promising prospects was a natural food product called red yeast rice. Red yeast rice is used extensively in Chinese cooking as a flavouring agent and food colouring for dishes such as tofu, Peking duck and Chinese spareribs.

Also known as Hung-chu of Hong-qu, red yeast rice is manufactured by fermenting rice with a specific strain of yeast called Monascus purpureus. Red yeast rice has been revered for its health enhancing properties for over two thousand years - records dating back to the Ming dynasty (1368 to 1644) describe red yeasts rice's role in promoting a healthy cardiovascular system by improving blood circulation and reducing clotting.

Chinese researchers discovered that red yeast rice contains a number of compounds - the most abundant of which is lovastatin, the same cholesterol lowering ingredient found in pharmaceutical statins such as Mevacor - that act as HMG-CoA reductase inhibitors. Researchers also reported finding a number of naturally occurring unsaturated fatty acids that appear to promote lower tryglyceride levels while increasing HDL Levels.

Red yeast has been proven effective in a number of clincal trials at promoting healthy cholesterol levels in subjects with total serum cholesterol greater than 5.2mmol/L. Lovastatin, the main active ingredient in red yeast rice, has been extensively researched; the results of which lend credible support for the effectiveness of red yeast rice in maintaining a healthy cardiovascular system.

Garlic
Allium Sativum L.
Specific ailments for which herbalists both modern and ancient recommend garlic include colds, (particularly recurrent ones) coughs, flu, chronic bronchitis whooping cough, ringworm, asthma, intestinal worms, fever and digestive, gallbladder and liver disorders. Of particular interest in recent years has been garlics purported ability, in addition to relieving stomach and intestinal upset, to treat atherosclerosis and heart disease risk factors such as high blood pressure, high cholesterol and blood clots.

The key ingredient in garlic, the odourless amino acid derivative alliin, converts into a substance called allicin when the garlic bulb is crushed or injured in any way.

Coenzyme Q10 (CoQ10)
Co-Enzyme Q10 (CoQ10), also known as ubiquinone, is a naturally occurring fat soluble vitamin like nutrient. Its fundamental role is that of a cellular energy carrier for mitochondria. It is involved in the stabilisation of cell membranes and is a potent antioxidant carried on LDL's (protects DNA) and is therefore cardio protective. Just as a car cannot function without a spark plug so our bodies cannot function with CoQ10.

Although it can be synthesised in the body, deficiencies have been reported. In fact, CoQ10 deficiency has been found in 39% of patients with high blood pressure. It is also known that the chemical statins lower CoQ10 (CoQ10 has therefore been empirically added to Natustat just in case). This finding alone suggests a need for CoQ10 supplementation. But CoQ10 appears to provide benefits beyond correction of a deficiency.

Vitamin B
Natustat contains vitamins, B3 (Niacin), B6 (pyridoxine), and B12 (cynacobalimin). Deficiencies of vitamin B12, B6 or folate may underlie some cases of elevated homocysteine levels.

ALLIUM SATIVUM (Garlic)
(The Active is Allicin)

Allicin

Carbbadox, ethoxyquin, ipriflavone, I-ascorbate 2-phosphate, closantel
http://www.chinaveterdrugs.com/prod.html

Herbal Allicin

Herbal Allicin is made of the refined ingredients from garlic allicin and the famous Chinese herbal medicine-sand brambles and saffron by modern biological technology based on the application of traditional medical treatment.
http://www.sdhuameng.com/bcsse02.htm

High Allicin Garlic
Garlic enhances immunity and protects against cancer. Its cardiovascular benefits include reversing atherosclerosis, lowering cholesterol and normalising blood pressure.
http://www.nenewalresearch.com/prods_garlic_530.htm

Allicin - The Healing properties of garlic
Allicin. Allium ursinum. The healing properties of garlic and a great wild alpine garlic product.
http://www.naturescynsations.com/allicin.htm

Two capsules contain:
CO Enzyme Q10
Pyridoxine
Cynocobalamin
Folic Acid
Red Yeast Rice Extract
Betaine Anhydrous
Vitamin E
Niacin
Allium Sativan

Dietary advice: Adults take one to four capsules per day or as prescribed by a healthcare practitioner. Discontinue use if any untoward side effects occur.